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氯吡格雷联合灯盏细辛注射液治疗急性脑梗死的临床疗效观察

Clinical Observation of Clopidogrel and Erigeron Breviscapus Injection in Treating Acute Cerebral Infarction

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  • 文献类型:期刊论文
  • 作者:陈磊  张婧   
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  • 文献出处:中药材
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摘要:

目的:探讨氯吡格雷联合灯盏细辛注射液对急性脑梗死的临床疗效。方法:2011年1月~2012年12月本院急诊科收治的急性脑梗死患者248例患者随机分为观察组和对照组(每组各124例),两组患者均接受常规基础治疗,对照组在常规治疗基础上接受氯吡格雷治疗,观察组在常规基础治疗的基础上接受氯吡格雷+灯盏细辛注射液治疗,疗程为2周。比较两组患者神经功能缺损程度评分(NIHSS)、血流变指标和综合临床疗效。结果:1治疗后7天和14天两组患者NIHSS评分均显著降低(P<0.01),且观察组患者NIHSS评分显著低于对照组(P<0.01);2治疗后7天和14天两组患者全血黏度、纤维蛋白原、凝血酶原时间和血小板黏附性与治疗前比较显著改善(P<0.01),且观察组患者上述血流变指标改善优于对照组(P<0.01);3两组患者治疗后综合临床疗效观察组总有效率为85.48%,显著高于对照组的75.00%(P<0.05)。结论:氯吡格雷联合灯盏细辛注射液对急性脑梗死有显著疗效,可改善患者神经功能和血流变,值得临床推荐。

Abstract:

Objective: To investigate the clinical effect of clopidogrel combined with Erigeron Injection on acute cerebral infarction. Methods: From January 2011 to December 2012, 248 patients with acute cerebral infarction admitted to the emergency department of our hospital were randomly divided into observation group and control group (124 cases in each group), and both groups received routine basic treatment. The control group The group received clopidogrel on the basis of conventional treatment. The observation group received clopidogrel plus erigeron injection on the basis of routine basic treatment for 2 weeks. The scores of neurological deficit (NIHSS), indexes of hemorheology and comprehensive clinical efficacy were compared between the two groups. Results: NIHSS scores of the two groups were significantly decreased (P <0.01) on the 7th and 14th days after treatment, and NIHSS scores of the observation group were significantly lower than those of the control group (P <0.01); 2 and 7 days and 14 days two The whole blood viscosity, fibrinogen, prothrombin time and platelet adhesion of the patients in the two groups were significantly improved compared with that before treatment (P <0.01). The improvement of hemorheology indexes in the observation group was better than that in the control group (P <0.01). The total effective rate of the three groups after treatment was 85.48%, which was significantly higher than that of the control group (75.00%, P <0.05). CONCLUSION: Clopidogrel combined with Erigeron Breviscapus injection has a significant effect on acute cerebral infarction and can improve neurological function and blood rheology in patients. It is worthy of clinical recommendation.

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