Objective: To investigate the clinical effect of clopidogrel combined with Erigeron Injection on acute cerebral infarction. Methods: From January 2011 to December 2012, 248 patients with acute cerebral infarction admitted to the emergency department of our hospital were randomly divided into observation group and control group (124 cases in each group), and both groups received routine basic treatment. The control group The group received clopidogrel on the basis of conventional treatment. The observation group received clopidogrel plus erigeron injection on the basis of routine basic treatment for 2 weeks. The scores of neurological deficit (NIHSS), indexes of hemorheology and comprehensive clinical efficacy were compared between the two groups. Results: NIHSS scores of the two groups were significantly decreased (P <0.01) on the 7th and 14th days after treatment, and NIHSS scores of the observation group were significantly lower than those of the control group (P <0.01); 2 and 7 days and 14 days two The whole blood viscosity, fibrinogen, prothrombin time and platelet adhesion of the patients in the two groups were significantly improved compared with that before treatment (P <0.01). The improvement of hemorheology indexes in the observation group was better than that in the control group (P <0.01). The total effective rate of the three groups after treatment was 85.48%, which was significantly higher than that of the control group (75.00%, P <0.05). CONCLUSION: Clopidogrel combined with Erigeron Breviscapus injection has a significant effect on acute cerebral infarction and can improve neurological function and blood rheology in patients. It is worthy of clinical recommendation.